Osteoarthritis year in review 2021: biology

This year in review on osteoarthritis biology summarizes a series of research articles published between the 2020 and 2021 Osteoarthritis Research Society International (OARSI) World Congress. Research hightlights were selected and discussed based on the new discoveries of OA’s cellular molecular mechanism, anatomical signatures, potential therapeutic targets, and regenerative therapy. Firstly, the recently developed potential therapeutic targets are summarized, and then the research focuses on TGF? and WNT signaling in joint tissue homeostasis, joint ageing and the dynamic of synolytics in OA joint, and the roles of TRP2, LDHA, OSCAR in cartilage homeostasis and OA joints are highlighted.