Modelling pathology: pain relationships in osteoarthritis

Osteoarthritis (OA) results from joint pathology that is clinically associated with pain. It may be the shared end result of various initiating factors, including trauma or immune-mediated inflammation. Historically, OA has been labeled as a ‘non-inflammatory arthritis’ or as a ‘wear-and-tear disease’. From a pathogenesis standpoint, these labels represent half-truths. Inflammatory mediators play a critical role in pathological processes across the joint, even though inflammation might be less pronounced in OA than in rheumatoid arthritis.