Joint distraction for osteoarthritis: clinical evidence and molecular mechanisms

Nature Reviews Rheumatology, Published online: 06 October 2021; doi:10.1038/s41584-021-00695-y

Knee joint distraction (KJD) is used to stimulate joint repair in advanced osteoarthritis. In the Review, Jansen and Mastbergen provide an overview of the clinical trial results of KJD treatment, current knowledge of the molecular mechanisms underlying joint repair in KJD, and future directions and unanswered questions in KJD research and treatment.